Supported nano gold catalyzed three-component coupling reactions of amines, dichloromethane and terminal alkynes (AHA)

[Display omitted] A simple and efficient method for the synthesis of pharmaceutically relevant propargylamines through one-pot three-component coupling reactions of amines, CH2Cl2, and terminal alkynes (AHA) using nano Au/CeO2 as a heterogeneous catalyst is reported. The catalyst is characterized by...

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Bibliographic Details
Published in:Tetrahedron letters 2015-03, Vol.56 (11), p.1302-1306
Main Authors: Berrichi, Amina, Bachir, Redouane, Benabdallah, Mohamed, Choukchou-Braham, Noureddine
Format: Article
Language:English
Subjects:
AHA
Coupling reaction
Heterogeneous catalysis
Nano gold
Propargylamine
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Summary:[Display omitted] A simple and efficient method for the synthesis of pharmaceutically relevant propargylamines through one-pot three-component coupling reactions of amines, CH2Cl2, and terminal alkynes (AHA) using nano Au/CeO2 as a heterogeneous catalyst is reported. The catalyst is characterized by DRX, DR-UV visible spectroscopy, and TEM. Gold particles are regularly distributed on ceria and range in size from 2 to 4nm.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.01.132