A straightforward synthesis of the CERT inhibitor (1′R,3′S)-HPA-12

[Display omitted] A straightforward synthesis of the CERT inhibitor HPA-12, (1′R,3′S)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide, is reported. The method requires only five synthetic steps from commercially available d-aspartic acid and leads to enantiopure HPA-12 in good overall yield...

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Bibliographic Details
Published in:Tetrahedron letters 2015-03, Vol.56 (13), p.1706-1708
Main Authors: Abad, José-Luis, Armero, Iván, Delgado, Antonio
Format: Article
Language:English
Subjects:
Ceramide
Chiral pool
Sphingolipids
Stereoselectivity
Transport inhibitor
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Summary:[Display omitted] A straightforward synthesis of the CERT inhibitor HPA-12, (1′R,3′S)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide, is reported. The method requires only five synthetic steps from commercially available d-aspartic acid and leads to enantiopure HPA-12 in good overall yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.02.060