An optimized and scalable synthesis of propylphosphonic anhydride for general use

[Display omitted] Propylphosphonic anhydride (T3P®) is an effective coupling and dehydrating agent, which has been used for a large number of chemical transformations. An efficient and versatile synthetic method is described to synthesize propylphosphonic anhydride (T3P®) in pure form, in an overall...

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Bibliographic Details
Published in:Tetrahedron letters 2015-04, Vol.56 (15), p.2014-2017
Main Authors: Pizova, Hana, Bobal, Pavel
Format: Article
Language:English
Subjects:
Amide coupling
Dehydrating agent
Michaelis–Arbuzov reaction
Michaelis–Becker reaction
Propylphosphonic anhydride
T3P
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Description
Summary:[Display omitted] Propylphosphonic anhydride (T3P®) is an effective coupling and dehydrating agent, which has been used for a large number of chemical transformations. An efficient and versatile synthetic method is described to synthesize propylphosphonic anhydride (T3P®) in pure form, in an overall yield of 51% in four steps from commercially available diethyl phosphonate.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.02.126