MgCl2·6H2O catalyzed highly efficient synthesis of 2-substituted-1H-benzimidazoles

[Display omitted] A series of substituted benzimidazoles were efficiently prepared by combining 1,2-phenylenediamine with aryl, heteroaryl aldehydes in the presence of catalytic amount of MgCl2·6H2O. The advantages of this new protocol are high conversion, clean reaction profile, use of less toxic c...

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Bibliographic Details
Published in:Tetrahedron letters 2015-05, Vol.56 (21), p.2691-2694
Main Authors: Ghosh, Pranab, Subba, Raju
Format: Article
Language:English
Subjects:
1,2-Phenylenediamine
Aldehydes
Benzimidazoles
DMF
MgCl2·6H2O
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Summary:[Display omitted] A series of substituted benzimidazoles were efficiently prepared by combining 1,2-phenylenediamine with aryl, heteroaryl aldehydes in the presence of catalytic amount of MgCl2·6H2O. The advantages of this new protocol are high conversion, clean reaction profile, use of less toxic catalyst, low cost, and environment friendly. The method is very simple mild and applicable to aryl as well as heteroaryl aldehydes without significant difference.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.04.001