Regioselective nitration of 3-fluoro-2-substituted benzoic acids

Fukui indices of local nucleophilicity correlate well with experimental findings. [Display omitted] The preparation of a series of 3-fluoro-2-substituted-6-nitro benzoic acids is described. The partially excellent regioselectivities observed in the nitration step can be rationalized in most cases us...

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Bibliographic Details
Published in:Tetrahedron letters 2015-05, Vol.56 (22), p.2860-2862
Main Authors: Hurth, Konstanze, Jacquier, Sébastien, Lehmann, Hansjörg, Wilcken, Rainer
Format: Article
Language:English
Subjects:
Anthranilic acids
Fukui indices
Local nucleophilicity
Regioselective nitration
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Summary:Fukui indices of local nucleophilicity correlate well with experimental findings. [Display omitted] The preparation of a series of 3-fluoro-2-substituted-6-nitro benzoic acids is described. The partially excellent regioselectivities observed in the nitration step can be rationalized in most cases using Fukui indices of local nucleophilicity.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.04.057