Cymoside, a monoterpene indole alkaloid with a hexacyclic fused skeleton from Chimarrhis cymosa

[Display omitted] Cymoside, an oxidized derivative of strictosidine with an unprecedented hexacyclic skeleton which includes a double bridge linking the indole and the monoterpene moieties has been isolated from the leaves of Chimarrhis cymosa. The structure of this alkaloid, its relative and absolu...

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Bibliographic Details
Published in:Tetrahedron letters 2015-09, Vol.56 (40), p.5377-5380
Main Authors: Lémus, Christelle, Kritsanida, Marina, Canet, Alban, Genta-Jouve, Grégory, Michel, Sylvie, Deguin, Brigitte, Grougnet, Raphaël
Format: Article
Language:English
Subjects:
Chimarrhis cymosa
Cymoside
Monoterpene indole alkaloid
Rubiaceae
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Summary:[Display omitted] Cymoside, an oxidized derivative of strictosidine with an unprecedented hexacyclic skeleton which includes a double bridge linking the indole and the monoterpene moieties has been isolated from the leaves of Chimarrhis cymosa. The structure of this alkaloid, its relative and absolute configurations have been established by spectroscopic data including 1D and 2D NMR experiments (COSY, HSQC, HMBC, NOESY), HRESIMS and electronic circular dichroïsm (ECD) calculations.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.07.066