Synthesis and cytotoxic evaluation of novel dihydrobenzo[h]cinnoline-5,6-diones

[Display omitted] A convenient one-pot multicomponent synthetic approach was developed en route to novel functionalized dihydrobenzo[h]cinnoline-5,6-diones using 2-hydroxy-1,4-naphthoquinone, methylhydrazine, and a variety of aromatic aldehydes. Fifteen new derivatives were thus prepared and subsequ...

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Bibliographic Details
Published in:Tetrahedron letters 2015-10, Vol.56 (43), p.5855-5858
Main Authors: Dang Thi, Tuyet Anh, Decuyper, Lena, Thi Phuong, Hoang, Vu Ngoc, Doan, Thanh Nguyen, Ha, Thanh Nguyen, Tra, Do Huy, Thanh, Huy Nguyen, Hung, D’hooghe, Matthias, Van Nguyen, Tuyen
Format: Article
Language:English
Subjects:
Cytotoxicity
Dihydrobenzo[h]cinnoline-5,6-diones
Domino reactions
Naphthoquinones
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Summary:[Display omitted] A convenient one-pot multicomponent synthetic approach was developed en route to novel functionalized dihydrobenzo[h]cinnoline-5,6-diones using 2-hydroxy-1,4-naphthoquinone, methylhydrazine, and a variety of aromatic aldehydes. Fifteen new derivatives were thus prepared and subsequently evaluated in terms of their cytotoxicity profile, revealing a promising anticancer activity of nine of the compounds against KB and Hep-G2 human tumor cell lines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.08.084