Exploratory studies towards a synthesis of bioactive kinamycin natural products

[Display omitted] A synthetic approach towards kinamycins that harnesses the proclivities of the norbornyl scaffold is unveiled to access the oxy-functionalized and actively side-armed cyclohexenoid ring-D of these bioactive natural products. This ring-D building block has been further elaborated to...

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Bibliographic Details
Published in:Tetrahedron letters 2015-12, Vol.56 (49), p.6919-6922
Main Authors: Modugu, Nagi Reddy, Vannada, Jagadeshwar, Mehta, Goverdhan
Format: Article
Language:English
Subjects:
Diazotetrahydrobenzo[b]fluorene
Kinamycin
Lithium triethylborohydride reduction
Lomaiviticin
Retro Diels–Alder reaction
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Summary:[Display omitted] A synthetic approach towards kinamycins that harnesses the proclivities of the norbornyl scaffold is unveiled to access the oxy-functionalized and actively side-armed cyclohexenoid ring-D of these bioactive natural products. This ring-D building block has been further elaborated to the tricyclic ABD ring system present in kinamycins.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.11.001