Silver-catalyzed one-step synthesis of multiply substituted quinolines

A silver-catalyzed formation of two C–C bonds for the construction of a series of polysubstituted quinolines from arylamines, aldehydes, and ketones or arylamines and 1,3-diketones has been developed. The transformation is effective for a broad range of substrates, including aliphatic, aromatic, cyc...

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Bibliographic Details
Published in:Tetrahedron letters 2016-01, Vol.57 (2), p.226-229
Main Authors: Xu, Xuefeng, Liu, Wenmin, Wang, Zhiqiang, Feng, Yuquan, Yan, Yanlei, Zhang, Xu
Format: Article
Language:English
Subjects:
Aldehydes
Amines
Ketones
Quinoline derivatives
Silver-catalyzed
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Summary:A silver-catalyzed formation of two C–C bonds for the construction of a series of polysubstituted quinolines from arylamines, aldehydes, and ketones or arylamines and 1,3-diketones has been developed. The transformation is effective for a broad range of substrates, including aliphatic, aromatic, cyclo ketone, and 1,3-diketone, thus enabling the expansion of constituent architectures on the heterocyclic framework. [Display omitted] A silver-catalyzed formation of C–C bond for the construction of a series of polysubstituted quinolines from arylamines, aldehydes, and ketones or arylamines and 1,3-diketones has been developed. The transformation is effective for a broad range of substrates, thus enabling the expansion of constituent architectures on the heterocyclic framework. This use of a single catalytic system to mediate chemical transformations in a synthetic operation is important for the development of new atom-economic strategies and this strategy is efficient in building complex structures from simple starting materials in an environmentally benign fashion.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.12.028