Transfer hydrogenative reductive amination of aldehydes in aqueous sodium formate solution

[Display omitted] A practical direct reductive amination reaction of aldehydes in aqueous sodium formate solution which produces amines in good yields under mild conditions is described. The amount and strength of the acid additives were critical factors to affect the reaction selectivities. This re...

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Bibliographic Details
Published in:Tetrahedron letters 2016-01, Vol.57 (4), p.509-511
Main Author: Zhu, Mengping
Format: Article
Language:English
Subjects:
Aqueous
Reductive amination
Ruthenium
Sodium formate
Transfer hydrogenation
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Summary:[Display omitted] A practical direct reductive amination reaction of aldehydes in aqueous sodium formate solution which produces amines in good yields under mild conditions is described. The amount and strength of the acid additives were critical factors to affect the reaction selectivities. This reductive amination method has great application potential for the synthesis of amine products given the mild conditions, short reaction time, the use of water as a solvent, and the use of benign hydrogen sources.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.12.072