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Metal free amination of 2-chloroazoles in aqueous medium

[Display omitted] A green approach for the synthesis of 2-amino azoles by the reaction of 2-chloro azoles with various types of amines using water as an environment friendly solvent at room temperature has been developed. The significant features of this methodology are short reaction time and easy...

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Bibliographic Details
Published in:Tetrahedron letters 2016-02, Vol.57 (6), p.637-640
Main Authors: Uday Kumar, R., Reddy, K. Harsha Vardhan, Anil Kumar, B.S.P., Satish, G., Reddy, V. Prakash, Nageswar, Y.V.D.
Format: Article
Language:English
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Summary:[Display omitted] A green approach for the synthesis of 2-amino azoles by the reaction of 2-chloro azoles with various types of amines using water as an environment friendly solvent at room temperature has been developed. The significant features of this methodology are short reaction time and easy product separation. This approach provides various biologically active compounds in good to excellent yields without adding any catalyst, ligand, or base.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.12.084