Diterpenoids and phenanthrenones from the leaves and stems of Strophioblachia fimbricalyx

[Display omitted] •Four new diterpenoids and one phenanthrenone were isolated from Strophioblachia fimbricalyx.•Fimbricalyxoid A, a cleistanthane diterpenoid, possesses a rare 3,20-oxybridge.•Fimbricalyxoid A absolute configuration established based on ECD calculation.•Fimbricalyxoids B–C are the fi...

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Bibliographic Details
Published in:Tetrahedron letters 2016-05, Vol.57 (21), p.2262-2265
Main Authors: Cheng, Li, Ji, Kai-long, Liao, Shang-gao, Gan, Li-she, Yang, Lin, Cao, Dong-hua, Liu, Ying-qian, Guo, Juan, Zhang, Ping, Lu, Chuan-li, Hu, Hua-bing, Xu, You-kai
Format: Article
Language:English
Subjects:
Cytotoxicity
Fimbricalyxoids
Norditerpenoids
Strophioblachia fimbricalyx
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Summary:[Display omitted] •Four new diterpenoids and one phenanthrenone were isolated from Strophioblachia fimbricalyx.•Fimbricalyxoid A, a cleistanthane diterpenoid, possesses a rare 3,20-oxybridge.•Fimbricalyxoid A absolute configuration established based on ECD calculation.•Fimbricalyxoids B–C are the first seco-ring-A pentanorditerpenoids. Five new compounds, namely fimbricalyxoids A–D (1–4) and 13-O-methylfimbricalyx B (5), together with five known compounds (6–10) were isolated from the leaves and stems of Strophioblachia fimbricalyx. Fimbricalyxoid A (1), a cleistanthane diterpenoid, possesses a rare 3,20-oxybridge, while fimbricalyxoids C–D (3–4) are the first seco-ring-A pentanorditerpenoids. Their structures and absolute configuration were established based on NMR and MS data and ECD calculation (1). Compounds 1, 6, and 7 exhibited cytotoxicity against five human tumor cell lines with IC50 values in the range of 1.4–8.2μM.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.04.034