Synthesis of ferrocene[c]pyridin-2(1H)-one derivatives via Pd(II)-catalyzed C–H activation reaction under air

[Display omitted] •Pd(II)-catalyzed C–H activation annulation of N-methoxylferrocenecarboxamide under air.•Novel N-methoxylferrocene[c]pyridin-2(1H)-one derivatives could be facilely synthesized.•Formation of the five-membered palladacycle with ferrocene core is rationalized. A Pd(II)-catalyzed C–H...

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Bibliographic Details
Published in:Tetrahedron letters 2016-10, Vol.57 (42), p.4676-4679
Main Authors: Liu, Hua-Yu, Mou, Rui-Qi, Sun, Chuan-Zhi, Zhang, Sheng-Yan, Guo, Dian-Shun
Format: Article
Language:English
Subjects:
Annulation
C–H activation
Ferrocene-fused heterocycle
N-Methoxy amide
Palladium-catalysis
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Summary:[Display omitted] •Pd(II)-catalyzed C–H activation annulation of N-methoxylferrocenecarboxamide under air.•Novel N-methoxylferrocene[c]pyridin-2(1H)-one derivatives could be facilely synthesized.•Formation of the five-membered palladacycle with ferrocene core is rationalized. A Pd(II)-catalyzed C–H activation annulation under air has been successfully developed for efficient synthesis of ferrocene[c]pyridin-2(1H)-one derivatives with high yields and good regiochemistry. This method shows highly atom- and step-economical access to prepare ferrocene-fused heterocycles under mild conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.09.006