One-pot reaction of pyranoindolones with phenylisocyanates: a simple and regioselective approach to β-carbolines

[Display omitted] •β-Carbolines are of high importance due to their presence in nature and diverse biological activity.•Direct, rapid (5min) and simple method to access β-carbolines is reported.•Thorough NMR analysis with full assignment of all 1H and 13C NMR chemical shifts. A versatile, regioselec...

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Bibliographic Details
Published in:Tetrahedron letters 2016-12, Vol.57 (49), p.5453-5456
Main Authors: Livadiotou, Despina, Hatzimimikou, Dimitra, Tsitsi, Dimitra, Tsiaras, Vassilios, Samatidou, Evanthia, Neochoritis, Constantinos G.
Format: Article
Language:English
Subjects:
3-Oxo-β-carbolines
Isocyanates
Microwave irradiation
One-pot reaction
Pyranoindolones
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Summary:[Display omitted] •β-Carbolines are of high importance due to their presence in nature and diverse biological activity.•Direct, rapid (5min) and simple method to access β-carbolines is reported.•Thorough NMR analysis with full assignment of all 1H and 13C NMR chemical shifts. A versatile, regioselective and novel approach towards 2-aryl-β-carbolin-3-ones from the reaction of pyranoindolones with phenylisocyanates is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.10.075