Recent advancements in dehydrogenative cross coupling reactions for CC bond formation

• Published in: Tetrahedron letters 2017-03, Vol.58 (9), p.803-824
• Main Authors: Varun, Begur Vasanthkumar, Dhineshkumar, Jayaraman, Bettadapur, Kiran R., Siddaraju, Yogesh, Alagiri, Kaliyamoorthy, Prabhu, Kandikere Ramaiah
• Format: Article
• Language: English
• Subjects: C[sbnd]C bond formation; C[sbnd]HC[sbnd]H functionalization; CDC; Oxidative coupling; Radical reactions
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2017.01.035

[Display omitted] •Recent advances on CDC reactions for CC bond formations.•CDC reactions are the closest to an ideal reaction that researchers have reached.•CDC reactions are step economical and atom economical.•CDC reactions are complementary to traditional coupling methods.•CDC reactions do not need prefunctionalized precursors. A significant number of reactions have appeared in the literature regarding cross dehydrogenative coupling (CDC) reactions over the years. This review aims to cover the advances in the area of CC bond formations via CDC reactions in the last six years (2011–2016). For the sake of brevity, the review has been subdivided into four major parts (i) sp3 – sp3, (ii) sp3 – sp2, (iii) sp2 – sp2 and (iv) sp3/sp2 – sp bond forming reactions. The reactions are discussed based on the principal catalyst system used, i.e. metal based, non-metal based or photocatalyst. Wherever necessary, the uniqueness of the methods has been shown by highlighting the substrate scope, along with proposed mechanisms.