An expedient synthesis of α,α-difluoro-β-hydroxy ketones via decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes

[Display omitted] •First decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes.•Highly convenient, yet efficient base- and metal-free process.•Structurally diverse α,α-difluoro-β-hydroxy ketones were obtained in high yields. A novel decarboxylative aldol reaction of α,α-difluoro...

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Bibliographic Details
Published in:Tetrahedron letters 2017-08, Vol.58 (34), p.3394-3397
Main Authors: Huang, Da-Kang, Lei, Zhong-Liang, Zhu, Yu-Jun, Liu, Zhen-Jiang, Hu, Xiao-Jun, Mao, Hai-Fang
Format: Article
Language:English
Subjects:
Decarboxylative aldol reaction
α,α-Difluoro-β-hydroxy ketone
α,α-Difluoro-β-keto acid
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Summary:[Display omitted] •First decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes.•Highly convenient, yet efficient base- and metal-free process.•Structurally diverse α,α-difluoro-β-hydroxy ketones were obtained in high yields. A novel decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes in the absence of any base and metal catalysts has been developed. This reaction provides a highly convenient and efficient method for the synthesis of structurally diverse α,α-difluoro-β-hydroxy ketones in good to excellent yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2017.07.060