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Recent topics of the natural product synthesis by Horner–Wadsworth–Emmons reaction
[Display omitted] •Recent advances in natural product synthesis by the HWE reaction are described.•Recent applications of the HWE reaction are categorized into six reaction types.•The HWE reaction is sometimes the only viable approach to the desired structure. The Horner–Wadsworth–Emmons (HWE) react...
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Published in: | Tetrahedron letters 2018-02, Vol.59 (7), p.568-582 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [Display omitted]
•Recent advances in natural product synthesis by the HWE reaction are described.•Recent applications of the HWE reaction are categorized into six reaction types.•The HWE reaction is sometimes the only viable approach to the desired structure.
The Horner–Wadsworth–Emmons (HWE) reaction has become well established among existing methodologies for the highly stereoselective olefination of carbonyl compounds. The reliability of this reaction in terms of its robustness, high stereoselectivity, and broad substrate scope permit retrosynthetic disconnection of the olefin bond in α,β-unsaturated carbonyl intermediates in natural product synthesis. This review discusses recent applications of the HWE reaction in natural product synthesis, highlighting its use for carbon chain elongation, coupling reactions of synthetic segments, ring-closing reactions, tandem reactions including HWE olefination, and asymmetric reactions. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2017.12.076 |