An efficient synthesis of indoles via a CuMgAl-LDH-catalyzed cyclization of 2-alkynylsulfonanilides

[Display omitted] •A green synthesis of indoles via CuMgAl-LDH-catalyzed cyclization is reported.•CuMgAl-LDH catalyst features facile preparation and unique dual activation.•This method shows broad substrate scope, mild conditions and high efficiency. A highly efficient method for the synthesis of i...

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Bibliographic Details
Published in:Tetrahedron letters 2018-10, Vol.59 (41), p.3719-3723
Main Authors: Zhang, Sheng-Yan, Sun, Shan-Gang, Guo, Yu-Shuang, Lu, Xiao-Fan, Guo, Dian-Shun
Format: Article
Language:English
Subjects:
2-Alkynylsulfonanilide
CuMgAl-LDH catalyst
Cyclization reaction
Hirshfeld surface analysis
Indole
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Summary:[Display omitted] •A green synthesis of indoles via CuMgAl-LDH-catalyzed cyclization is reported.•CuMgAl-LDH catalyst features facile preparation and unique dual activation.•This method shows broad substrate scope, mild conditions and high efficiency. A highly efficient method for the synthesis of indoles has been successfully developed via a CuMgAl-LDH-catalyzed intramolecular annulation reaction of 2-alkynylsulfonanilides. This CuMgAl-LDH catalyst features facile preparation, recovery, and reuse at least seven times without a marked loss in the catalytic activity, as well as the unique dual activation. Moreover, the crystal structures and Hirshfeld surface analysis of typical indole compounds were also presented.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2018.09.009