Ruthenium dihydride complexes as enyne metathesis catalysts

[Display omitted] •RuH2Cl2(PR3)2 complexes act as catalysts for enyne metathesis.•Mechanistic studies implicate a ruthenium vinylidene as the active catalyst.•Many good yields are obtained with 1,6 and 1,7-enynes using these catalysts. Ruthenium–catalyzed enyne metathesis is a reliable and efficient...

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Bibliographic Details
Published in:Tetrahedron letters 2018-12, Vol.59 (51), p.4471-4474
Main Authors: Dolan, Martin A., Dixon, Alexandre D.C., Chisholm, John D., Clark, Daniel A.
Format: Article
Language:English
Subjects:
1,3-Diene
Alkyne
Dihydride
Enyne
Metathesis
Ruthenium
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Summary:[Display omitted] •RuH2Cl2(PR3)2 complexes act as catalysts for enyne metathesis.•Mechanistic studies implicate a ruthenium vinylidene as the active catalyst.•Many good yields are obtained with 1,6 and 1,7-enynes using these catalysts. Ruthenium–catalyzed enyne metathesis is a reliable and efficient method for the formation of 1,3-dienes, a common structural motif in synthetic organic chemistry. The development of new transition-metal complexes competent to catalyze enyne metathesis reactions remains an important research area. This report describes the use of ruthenium (IV) dihydride complexes with the general structure RuH2Cl2(PR3)2 as new catalysts for enyne metathesis. These ruthenium (IV) dihydrides have been largely unexplored as catalysts in metathesis-based transformations. The reactivity of these complexes with 1,6 and 1,7-enynes was investigated. The observed reaction products are consistent with the metathesis activity occurring through a ruthenium vinylidene intermediate.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2018.11.016