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Ru-catalyzed synthesis of substituted phthalides through C–H bond activation and functionalization
[Display omitted] •Synthesis of phthalides using phthalic anhydride derivatives for the first time.•The structure of a desired product was admitted by X-ray crystallography.•Mechanism includes CH bond activation, vinylation, decarboxylation and annulation.•A number of corresponding phthalides were o...
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Published in: | Tetrahedron letters 2019-03, Vol.60 (10), p.699-702 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [Display omitted]
•Synthesis of phthalides using phthalic anhydride derivatives for the first time.•The structure of a desired product was admitted by X-ray crystallography.•Mechanism includes CH bond activation, vinylation, decarboxylation and annulation.•A number of corresponding phthalides were obtained in good yields.
Synthesis of substituted phthalides through a ruthenium-catalyzed reaction of phthalic anhydrides with acrylates is described. The reaction proceeds via CH bond activation and leads to the formation of vinylated phthalides through a successive double vinylation accompanied by decarboxylation and annulation reactions. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2018.12.005 |