Pleosporalesones A–B, two unique polyketides isolated from Pleosporales sp

[Display omitted] •Pleosporalesones A–B (1–2), two unique polyketides isolated from fungi.•A new class of polyketides bearing an unusual 6/6/7/6 tetracyclic ring system.•A plausible biosynthetic pathway for pleosporalesones A–B (1–2) was proposed. Two unique polyketides, pleosporalesones A–B (1–2),...

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Bibliographic Details
Published in:Tetrahedron letters 2019-01, Vol.60 (4), p.375-377
Main Authors: Zhang, Li-Hua, Bai, Jian, Yan, Dao-Jiang, Wang, Ya-Nan, Zhang, Ya-Long, Li, Li, Liu, Bing-Yu, Hu, You-Cai
Format: Article
Language:English
Subjects:
Benzoannulated cycloheptanone
Pleosporales sp
Pleosporalesones A–B
Polyketides
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Summary:[Display omitted] •Pleosporalesones A–B (1–2), two unique polyketides isolated from fungi.•A new class of polyketides bearing an unusual 6/6/7/6 tetracyclic ring system.•A plausible biosynthetic pathway for pleosporalesones A–B (1–2) was proposed. Two unique polyketides, pleosporalesones A–B (1–2), bearing an unusual 6/6/7/6 tetracyclic ring system consisting of a chromone ring and a benzoannulated cycloheptanone ring, were isolated from the solid cultures of Pleosporales sp.. The chemical structures were elucidated by analyses of their extensive spectroscopic data, including 1D/2D NMR, ORD, CD and HR-ESI-MS, and the absolute configurations were established by comparison of their experimental circular dichroism data with those calculated. A plausible biosynthetic pathway for pleosporalesones A–B was proposed.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2018.12.057