Catalytic removal of tert-butyldimethylsilyl (TBS) ether by PVP-I

[Display omitted] •A PVP-I catalyzed OTBS deprotection method was developed with simple work-up process.•OTBS and OTHP could be removed simultaneously.•Chemoselective deprotection of TBS ethers in the presence of TIPS and TBDPS. A mild, efficient and rapid protocol the deprotection of alcoholic TBDM...

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Bibliographic Details
Published in:Tetrahedron letters 2019-09, Vol.60 (39), p.150831, Article 150831
Main Authors: Lu, Guangying, Wang, Di, Ren, Jiangmeng, Ke, Yanxiong, Zeng, Bu-Bing
Format: Article
Language:English
Subjects:
Catalytic
Deprotection
PVP-I
TBS ether
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Summary:[Display omitted] •A PVP-I catalyzed OTBS deprotection method was developed with simple work-up process.•OTBS and OTHP could be removed simultaneously.•Chemoselective deprotection of TBS ethers in the presence of TIPS and TBDPS. A mild, efficient and rapid protocol the deprotection of alcoholic TBDMS ethers using PVP-1 as catalyst in methanol, the procedure of deprotection of various TBDMS ethers were found to be very convenient, easy work-up, high yielding.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2019.05.059