Dicitrinones E and F, citrinin dimers from the marine derived fungus Penicillium citrinum HDN-152-088

[Display omitted] •Two new two new citrinin dimers with rare C-7/C-7′ carbon-bridges were isolated from a marine derived fungus.•Compound 2 was the first citrinin dimer consisted of two mono-benzene monomers.•Compound 1 displayed antioxidant activity. Two new citrinin dimers named dicitrinones E and...

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Bibliographic Details
Published in:Tetrahedron letters 2019-10, Vol.60 (44), p.151182, Article 151182
Main Authors: Wang, Lu, Li, Changlong, Yu, Guihong, Sun, Zichao, Zhang, Guojian, Gu, Qianqun, Zhu, Tianjiao, Che, Qian, Guan, Huashi, Li, Dehai
Format: Article
Language:English
Subjects:
Antioxidant activity
Citrinin dimers
Marine fungus
Penicillium citrinum
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Summary:[Display omitted] •Two new two new citrinin dimers with rare C-7/C-7′ carbon-bridges were isolated from a marine derived fungus.•Compound 2 was the first citrinin dimer consisted of two mono-benzene monomers.•Compound 1 displayed antioxidant activity. Two new citrinin dimers named dicitrinones E and F (1 and 2), together with one biogenetically related known citrinin monomer (3), were isolated from the marine derived fungus Penicillium citrinum HDN-152-088. All structures including the absolute configurations were elucidated on the basis of comprehensive spectroscopic data, and assisted by ECD calculations. Among them, compounds 1 and 2 belong to the class of citrinin dimers with a rare carbon-bridged C-7/C-7′ linkage. Compound 1 displayed antioxidant activity with IC50 value of 23.73 μM.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2019.151182