Loading…
Novel one-pot approach to 2-aminofuran derivatives via multicomponent reaction of 3-hydroxy-4H-pyran-4-ones, α-ketoaldehydes and methylene active nitriles
[Display omitted] •The novel one-pot synthesis of substituted 2-aminofurans was elaborated.•The synthesis involved multicomponent reaction of 3-hydroxy-4H-pyran-4-ones.•Easily accessible starting materials, mild reaction conditions, high yields.•Typical structure was confirmed by X-ray crystallograp...
Saved in:
Published in: | Tetrahedron letters 2020-10, Vol.61 (41), p.152384, Article 152384 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | [Display omitted]
•The novel one-pot synthesis of substituted 2-aminofurans was elaborated.•The synthesis involved multicomponent reaction of 3-hydroxy-4H-pyran-4-ones.•Easily accessible starting materials, mild reaction conditions, high yields.•Typical structure was confirmed by X-ray crystallographic analysis.
A novel efficient one-pot method for the preparation of 2-aminofurans was developed based on multicomponent reaction of 3-hydroxy-4H-pyran-4-ones, α-ketoaldehydes and methylene active nitriles. A distinctive feature of the proposed approach is the formation of 2-aminofurans in contrast to related literature methods leading to 2-aminopyrans. The advantages of this synthesis include high yields, mild reaction conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structure of one of the 2-aminofuran derivatives was determined by X-ray diffraction. |
---|---|
ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2020.152384 |