Efficient synthesis of 2H-chromene derivatives via a dual-organocatalytic reaction

[Display omitted] •Highly selective synthesis of 2H-chromenes with various substituents.•Dual organocatalyst system.•Operational simplicity and mild reaction conditions. An efficient synthetic method was developed for the selective construction of 2H-chromene derivatives from various salicylaldehyde...

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Bibliographic Details
Published in:Tetrahedron letters 2020-10, Vol.61 (42), p.152402, Article 152402
Main Authors: Somprasong, Siriphong, Prasitwatcharakorn, Watcharapon, Luanphaisarnnont, Torsak
Format: Article
Language:English
Subjects:
2H-Chromenes
Catalysis
p-Toluenesulfonic acid
Pyrrolidine
Regioselective synthesis
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Summary:[Display omitted] •Highly selective synthesis of 2H-chromenes with various substituents.•Dual organocatalyst system.•Operational simplicity and mild reaction conditions. An efficient synthetic method was developed for the selective construction of 2H-chromene derivatives from various salicylaldehydes and acetylenic diesters using a dual catalyst system (p-toluenesulfonic acid monohydrate and pyrrolidine). The advantages of this transformation include high selectivity, good functional group tolerance, operational simplicity, and mild reaction conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2020.152402