Iron-catalyzed oxidative amidation of acylhydrazines with amines

[Display omitted] A new approach for amide bond formation via a mild and efficient Iron-catalyzed cross-coupling reaction of acylhydrazines and amines using TBHP as oxidant is described. This protocol is compatible with a wide range of amines and acylhydrazines. In addition, the synthetic applicatio...

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Bibliographic Details
Published in:Tetrahedron letters 2021-09, Vol.80, p.153316, Article 153316
Main Authors: Wang, Yi-Jie, Zhang, Guo-Yu, Shoberu, Adedamola, Zou, Jian-Ping
Format: Article
Language:English
Subjects:
Acylhydrazine
Amide
Cross-coupling reaction
Iron-catalyst
Radical reaction
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Summary:[Display omitted] A new approach for amide bond formation via a mild and efficient Iron-catalyzed cross-coupling reaction of acylhydrazines and amines using TBHP as oxidant is described. This protocol is compatible with a wide range of amines and acylhydrazines. In addition, the synthetic application of the reaction is presented.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153316