Iridium-catalyzed oxidative coupling and cyclization of NH isoquinolones with olefins leading to isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives

[Display omitted] The iridium-catalyzed oxidative coupling and cyclization of NH isoquinolones with olefins has been realized. Most isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives were obtained in moderate to good yields. Several derivatization reactions including functional group conversion and f...

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Bibliographic Details
Published in:Tetrahedron letters 2022-05, Vol.97, p.153779, Article 153779
Main Authors: Yan, Kelu, Liu, Xiao, Liu, Min, Wen, Jiangwei, Du, Mingyue, Fu, Yingxue, Chen, Wenxin
Format: Article
Language:English
Subjects:
C[sbnd]H activation
Iridium
Isoindolo[2,1-b]isoquinolin-5(7H)-ones
Isoquinolones
Olefins
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Summary:[Display omitted] The iridium-catalyzed oxidative coupling and cyclization of NH isoquinolones with olefins has been realized. Most isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives were obtained in moderate to good yields. Several derivatization reactions including functional group conversion and further CH/olefin coupling were also performed. This transformation realized the less developed Cp*Ir(III) catalyzed coupling and cyclization reaction of NH substrates with olefins.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153779