Cobalt-catalyzed decarboxylative oxyalkylation of styrenes with α-cyanoacid: Access to γ‑ketonitriles

[Display omitted] A cobalt-catalyzed decarboxylative oxyalkylation of styrenes with α-cyanoacid has been established, leading to a variety of γ‑ketonitriles in moderate yields. α-Cyanoacid was applied as the nitrile sources. This methodology was distinguished by operational simplicity, easily availa...

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Bibliographic Details
Published in:Tetrahedron letters 2022-05, Vol.98, p.153807, Article 153807
Main Authors: Chen, Rongxiang, Wang, Yu, Wang, Zhan-Yong, Ma, Xueji, Xu, Canran, Wang, Kai-Kai, Sun, Aili
Format: Article
Language:English
Subjects:
Cobalt catalysis
Decarboxylative oxyalkylation
Styrenes
α-Cyanoacids
γ-Ketonitriles
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Summary:[Display omitted] A cobalt-catalyzed decarboxylative oxyalkylation of styrenes with α-cyanoacid has been established, leading to a variety of γ‑ketonitriles in moderate yields. α-Cyanoacid was applied as the nitrile sources. This methodology was distinguished by operational simplicity, easily available starting materials and good functionality tolerance.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153807