2-Guanidinoethanesulfonyl Sesquiterpenes from the Marine Sponge Agelas nakamurai

[Display omitted] A new 2-guanidinoethanesulfonyl sesquiterpene, cyclohexylagelasidine A (1), and a known compound (–)-agelasidine A (2), were isolated in the present chemical investigation of a marine sponge Agelas nakamurai. Cyclohexylagelasidine A (1) is the first 2-guanidinoethanesulfonyl sesqui...

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Bibliographic Details
Published in:Tetrahedron letters 2022-08, Vol.103, p.153964, Article 153964
Main Authors: Fu, Chung-Wei, Lin, You-Cheng, Chiou, Shu-Fen, Huang, Tzu-Yin, Yang, Yen-Ju, Wu, Shih-Hsiung, Chen, Shu-Li, Lin, Chi-Chien, Wang, Hui-Chun, Yu, Meng-Chen, Sheu, Jyh-Horng
Format: Article
Language:English
Subjects:
2-Guanidinoethanesulfonyl sesquiterpenes
Agelas nakamurai
Anti-inflammatory activity
Antibacterial activity
Cyclohexylagelasidine A
Cytotoxicity
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Summary:[Display omitted] A new 2-guanidinoethanesulfonyl sesquiterpene, cyclohexylagelasidine A (1), and a known compound (–)-agelasidine A (2), were isolated in the present chemical investigation of a marine sponge Agelas nakamurai. Cyclohexylagelasidine A (1) is the first 2-guanidinoethanesulfonyl sesquiterpene with a carbocyclic ring in nature. Moreover, the major metabolite 2 showed cytotoxic, antibacterial, and anti-inflammatory activities.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153964