Progress on total synthesis and their divergent transformations of aryltetrahydrofuran-type lignans

[Display omitted] Total synthesis of biologically important tetrahydrofuran (THF) lignan natural products with different substituted types was first summarized, and the construction strategies of THF rings was especially focused. Furthermore, divergent transformations of these THF lignans to other p...

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Bibliographic Details
Published in:Tetrahedron letters 2023-01, Vol.115, p.154309, Article 154309
Main Authors: Yao, Si-Chen, Xiao, Jian, Nan, Guang-Ming, Peng, Yu
Format: Article
Language:English
Subjects:
Cyclolignans
Lignans
Synthetic methods
Tetrahydrofuran
Total Synthesis
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Summary:[Display omitted] Total synthesis of biologically important tetrahydrofuran (THF) lignan natural products with different substituted types was first summarized, and the construction strategies of THF rings was especially focused. Furthermore, divergent transformations of these THF lignans to other polycyclic lignan natural products were introduced simultaneously, demonstrating plausible biosynthetic relationships among them. We wish that this review would stimulate the development of new synthetic methods to THF lignan natural products and beyond.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.154309