New azaspirene derivatives from marine-derived fungus Aspergillus micronesiensis NF666

[Display omitted] Azaspirene derivatives are widespread natural products in fungi. Here we reported five new azaspirenes A-E (1–5) from the marine mud-derived endophytic fungus Aspergillus micronesiensis NF666. Their structures were unambiguously determined by an extensive analysis of HRESIMS and NM...

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Bibliographic Details
Published in:Tetrahedron letters 2023-06, Vol.123, p.154566, Article 154566
Main Authors: Jiao, Fang Wen, Xing, Yin Nan, Liu, Tian Yu, Wu, Feng, Li, Wei, Jiao, Rui Hua
Format: Article
Language:English
Subjects:
Azaspirene derivatives
Biosynthesis
Endophytic fungus
Structure elucidation
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Summary:[Display omitted] Azaspirene derivatives are widespread natural products in fungi. Here we reported five new azaspirenes A-E (1–5) from the marine mud-derived endophytic fungus Aspergillus micronesiensis NF666. Their structures were unambiguously determined by an extensive analysis of HRESIMS and NMR data. All compounds were evaluated on antimicrobial activities against five pathogens by the agar diffusion method. Moreover, a plausible biosynthetic pathway of azaspirenes A (1) is proposed in this work.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2023.154566