A practical, tandem and protecting-group-free synthesis of (+)-rosmarinic acid and its analogues

[Display omitted] A short, tandem and protecting-group-free total synthesis of (+)-rosmarinic acid and related ester derivatives from (+)-danshensu (or corresponding aryl lactic acid) and related hydroxybenzaldehydes in 54 %∼87 % overall yield is described. The key step is the Meldrum’s acid mediate...

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Bibliographic Details
Published in:Tetrahedron letters 2024-01, Vol.135, p.154879, Article 154879
Main Authors: Sun, Ying, Fan, Peinan, Zhao, Xiaolong, Liu, Dan, Ru, Yilin, Bai, Yujun, Bai, Yajun, Zheng, Xiaohui
Format: Article
Language:English
Subjects:
(+)-rosmarinic acid
Knoevenagel condensation
Protecting-group-free
Synthesis
Tandem reaction
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Summary:[Display omitted] A short, tandem and protecting-group-free total synthesis of (+)-rosmarinic acid and related ester derivatives from (+)-danshensu (or corresponding aryl lactic acid) and related hydroxybenzaldehydes in 54 %∼87 % overall yield is described. The key step is the Meldrum’s acid mediate tandem classical Knoevenagel condensation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2023.154879