A practical, tandem and protecting-group-free synthesis of (+)-rosmarinic acid and its analogues

[Display omitted] A short, tandem and protecting-group-free total synthesis of (+)-rosmarinic acid and related ester derivatives from (+)-danshensu (or corresponding aryl lactic acid) and related hydroxybenzaldehydes in 54 %∼87 % overall yield is described. The key step is the Meldrum’s acid mediate...

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Published in:Tetrahedron letters 2024-01, Vol.135, p.154879, Article 154879
Main Authors: Sun, Ying, Fan, Peinan, Zhao, Xiaolong, Liu, Dan, Ru, Yilin, Bai, Yujun, Bai, Yajun, Zheng, Xiaohui
Format: Article
Language:English
Subjects:
(+)-rosmarinic acid
Knoevenagel condensation
Protecting-group-free
Synthesis
Tandem reaction
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cited_by cdi_FETCH-LOGICAL-c306t-aa44b7ef71748e8c52ee2429d607d5423644e4aca78e37730ff22a6163a029313
cites cdi_FETCH-LOGICAL-c306t-aa44b7ef71748e8c52ee2429d607d5423644e4aca78e37730ff22a6163a029313
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container_start_page 154879
container_title Tetrahedron letters
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creator Sun, Ying
Fan, Peinan
Zhao, Xiaolong
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Bai, Yajun
Zheng, Xiaohui
description [Display omitted] A short, tandem and protecting-group-free total synthesis of (+)-rosmarinic acid and related ester derivatives from (+)-danshensu (or corresponding aryl lactic acid) and related hydroxybenzaldehydes in 54 %∼87 % overall yield is described. The key step is the Meldrum’s acid mediate tandem classical Knoevenagel condensation.
doi_str_mv 10.1016/j.tetlet.2023.154879
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source ScienceDirect Journals
subjects (+)-rosmarinic acid
Knoevenagel condensation
Protecting-group-free
Synthesis
Tandem reaction
title A practical, tandem and protecting-group-free synthesis of (+)-rosmarinic acid and its analogues
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