A facile approach toward γ-branched amines via copper-catalyzed 1,3-aminoalkynylation and aminobromination of arylcyclopropanes

[Display omitted] A copper-catalyzed 1,3-aminoalkynylation or 1,3-aminobromination of arylcyclopropane with N-fluorobenzenesulfonimide (NFSI) and trimethoxy[(trimethylsilyl)ethynyl]silane or LiBr have been successfully developed. Through this strategy, a wide range of γ-alkylnyl-/γ-bromino-γ-branche...

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Bibliographic Details
Published in:Tetrahedron letters 2024-03, Vol.137, p.154934, Article 154934
Main Authors: Bu, Yu, Zhang, Yingzi, Shangguan, Xiaoyan, Sun, Shaoguang, Li, Yan, Zhang, Qian
Format: Article
Language:English
Subjects:
Aminoalkynylation
Aminobromination
Arylcyclopropane
Branced amine
Radical
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Summary:[Display omitted] A copper-catalyzed 1,3-aminoalkynylation or 1,3-aminobromination of arylcyclopropane with N-fluorobenzenesulfonimide (NFSI) and trimethoxy[(trimethylsilyl)ethynyl]silane or LiBr have been successfully developed. Through this strategy, a wide range of γ-alkylnyl-/γ-bromino-γ-branched amine derivatives were efficiently synthesized in good yields under mild conditions.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2024.154934