Candida antarctica lipase B catalyzed condensation reactions: Water mediated chemo-enzymatic synthesis of different heterocycles

[Display omitted] •Development of water mediated and enzyme catalyzed method towards heterocycles.•Environmentally friendly approach.•Synthesis and characterization of 27 different heterocycles in 76–92 % yield. A water-mediated, chemoenzymatic reaction has been developed for synthesizing various he...

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Bibliographic Details
Published in:Tetrahedron letters 2024-12, Vol.153, p.155371, Article 155371
Main Authors: Malasala, Satyaveni, Polomani, Anusha, Gour, Jitendra, Nanduri, Srinivas
Format: Article
Language:English
Subjects:
benzimidazole
carboxylic ester hydrolases
Condensation
green chemistry
Green chemistry approach
Heterocycles
Lipase-B
Pseudozyma antarctica
pyrimidines
Water-mediated
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Summary:[Display omitted] •Development of water mediated and enzyme catalyzed method towards heterocycles.•Environmentally friendly approach.•Synthesis and characterization of 27 different heterocycles in 76–92 % yield. A water-mediated, chemoenzymatic reaction has been developed for synthesizing various heterocycles. This reported method is compatible with various condensation reactions and multi-component reactions, such as the Biginelli reaction. It offers direct access to benzothiazole, benzimidazole, benzoxazole, quinazolinone, and pyrimidines using straightforward reaction conditions, adhering to green chemistry principles.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2024.155371