Serotonin release assay (SRA)-negative HIT, a newly recognized entity: Implications for diagnosis and management

•Some platelet-activating HIT antibodies may not induce serotonin release in the SRA.•The PEA detected SRA-negative antibodies in the two HIT patients described•Recognition of “SRA-negative HIT” is important for appropriate patient management.

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Bibliographic Details
Published in:Thrombosis research 2018-12, Vol.172, p.169-171
Main Authors: Pandya, Komal A., Johnson, Eric G., Davis, George A., Padmanabhan, Anand
Format: Article
Language:English
Subjects:
Heparin-induced thrombocytopenia
HIT
Thrombocytopenia
Thrombosis
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Description
Summary:•Some platelet-activating HIT antibodies may not induce serotonin release in the SRA.•The PEA detected SRA-negative antibodies in the two HIT patients described•Recognition of “SRA-negative HIT” is important for appropriate patient management.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2018.10.022