Obesity: Effects on bone marrow homeostasis and platelet activation

Obesity is a major health issue that can increase the risk of cardiovascular morbidity and mortality. Obesity is characterized by an elevated prothrombotic state in which dysregulated platelet activation is a major component due to accumulation of adipose depots, insulin resistance, endothelial dysf...

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Bibliographic Details
Published in:Thrombosis research 2023-11, Vol.231, p.195-205
Main Authors: Vauclard, Alicia, Bellio, Marie, Valet, Colin, Borret, Maxime, Payrastre, Bernard, Severin, Sonia
Format: Article
Language:English
Subjects:
Bone marrow adipocytes
Megakaryocytes
Obesity
Platelets
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Summary:Obesity is a major health issue that can increase the risk of cardiovascular morbidity and mortality. Obesity is characterized by an elevated prothrombotic state in which dysregulated platelet activation is a major component due to accumulation of adipose depots, insulin resistance, endothelial dysfunction, low-grade chronic inflammation and oxidative stress. Obesity also alters the homeostasis of the bone marrow, the site where megakaryopoiesis and platelet production take place, which include bone marrow adipose tissue as an important constituent of this microenvironment. Here, we provide an up-to-date review focusing on bone marrow adipose tissue and the influence of obesity on megakaryocytes and platelets that increases the cardiovascular risk.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2022.10.008