Generic GPCR residue numbers – aligning topology maps while minding the gaps

Highlights • Generic residue numbering for GPCR classes A, B, C, and F is reviewed. • A new complementary structure-based numbering system is proposed that accounts for helix bulges and constrictions. • Illustrative examples of cross-class and structure-based numbering are presented. • GPCRDB web to...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2015-01, Vol.36 (1), p.22-31
Main Authors: Isberg, Vignir, de Graaf, Chris, Bortolato, Andrea, Cherezov, Vadim, Katritch, Vsevolod, Marshall, Fiona H, Mordalski, Stefan, Pin, Jean-Philippe, Stevens, Raymond C, Vriend, Gerrit, Gloriam, David E
Format: Article
Language:English
Subjects:
Advanced Basic Science
G protein-coupled receptor
Humans
ligand binding
mutational effects
Protein Conformation
Receptors, G-Protein-Coupled - chemistry
Receptors, G-Protein-Coupled - classification
Sequence Alignment
sequence alignments
Sequence Analysis, Protein
structural motifs
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Summary:Highlights • Generic residue numbering for GPCR classes A, B, C, and F is reviewed. • A new complementary structure-based numbering system is proposed that accounts for helix bulges and constrictions. • Illustrative examples of cross-class and structure-based numbering are presented. • GPCRDB web tools to number any receptor sequence or structure are summarized.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2014.11.001