Effects of electromagnetic radiation on morphology and TGF-β3 expression in mouse testicular tissue

Highlights • EMP exposure with 400 pulses causes testicular tissue degeneration and exfoliation. • EMP exposure with 400 pulses increase apoptotic rate of testicular tissue. • EMP exposure with 400 pulses increases the TGF-β3 expression in testicular tissue. • TGF-β3 has regulatory functions in the...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2013-08, Vol.310, p.8-14
Main Authors: Luo, Yaning, Wang, Xiaowu, Chen, Yongbin, Xu, Shenglong, Ding, Guirong, Shi, Changhong
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - radiation effects
blood
Blood testes barrier
Blood-Testis Barrier - radiation effects
Blotting, Western
Dose-Response Relationship, Radiation
Electromagnetic pulse
Electromagnetic Radiation
Emergency
extracellular matrix
Fluorescent Antibody Technique
In Situ Nick-End Labeling
irradiation
Male
messenger RNA
Mice
Mice, Inbred BALB C
Occludin - biosynthesis
Permeability
protein synthesis
proteins
shrinkage
spermatogenesis
spermiation
steroids
testes
Testis - blood supply
Testis - metabolism
Testis - pathology
Testis - radiation effects
TGF-β3
tight junctions
Tight Junctions - metabolism
Tight Junctions - radiation effects
toxicology
transforming growth factor beta 3
Transforming Growth Factor beta3 - biosynthesis
Whole Body Imaging
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Summary:Highlights • EMP exposure with 400 pulses causes testicular tissue degeneration and exfoliation. • EMP exposure with 400 pulses increase apoptotic rate of testicular tissue. • EMP exposure with 400 pulses increases the TGF-β3 expression in testicular tissue. • TGF-β3 has regulatory functions in the increase in BTB permeability induced by EMP.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2013.05.004