Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures

Highlights • No published or well recognized MOA for Cr(VI)-induced lung tumors exists. • MOA analysis for Cr(VI)-induced lung cancer was conducted to inform risk assessment. • Cr(VI) epidemiologic, toxicokinetic, toxicological, mechanistic data were evaluated. • Weight of evidence does not support...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2014-11, Vol.325, p.160-179
Main Authors: Proctor, Deborah M, Suh, Mina, Campleman, Sharan L, Thompson, Chad M
Format: Article
Language:English
Subjects:
Animals
Cancer risk assessment
Carcinogens, Environmental - adverse effects
Cell Transformation, Neoplastic - chemically induced
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Chromium - adverse effects
DNA Damage
Dose-Response Relationship, Drug
Emergency
Gene Expression Regulation, Neoplastic
Hexavalent chromium [Cr(VI)]
Humans
Inhalation Exposure - adverse effects
Lung - drug effects
Lung - metabolism
Lung - pathology
Lung cancer
Lung Neoplasms - chemically induced
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Mode of action
Occupational Exposure - adverse effects
Risk Assessment
Risk Factors
Time Factors
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Summary:Highlights • No published or well recognized MOA for Cr(VI)-induced lung tumors exists. • MOA analysis for Cr(VI)-induced lung cancer was conducted to inform risk assessment. • Cr(VI) epidemiologic, toxicokinetic, toxicological, mechanistic data were evaluated. • Weight of evidence does not support a mutagenic MOA for Cr(VI)-induced lung cancer. • Non-linear approaches should be considered for evaluating Cr(VI) lung cancer risk.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2014.08.009