A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement

Highlights • Carbon monoxide poisoning effects go far beyond hemoglobin poisoning. • Carbon monoxide creates reactive oxygen species and promotes nitric oxide release. • Carbon monoxide acts directly on neurologic and cardiac ion channels. • Certain oxygen therapies may not be the best therapy for c...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2015-08, Vol.334, p.45-58
Main Authors: Roderique, Joseph D, Josef, Christopher S, Feldman, Michael J, Spiess, Bruce D
Format: Article
Language:English
Subjects:
Animals
Antidotes - therapeutic use
Carbon Dioxide - blood
Carbon Dioxide - toxicity
Carbon monoxide poisoning
Carbon Monoxide Poisoning - blood
Carbon Monoxide Poisoning - physiopathology
Carbon Monoxide Poisoning - therapy
Carboxyhemoglobin - metabolism
Cardiac ion channels
Emergency
Gases
Gasotransmitter
Humans
Hyperbaric Oxygenation
Ion Channels - drug effects
Ion Channels - metabolism
Molecular Targeted Therapy
Neuronal ion channels
Nitric oxide
Nitric Oxide - metabolism
Reactive oxygen species
Reactive Oxygen Species - metabolism
Signal Transduction - drug effects
Treatment Outcome
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Summary:Highlights • Carbon monoxide poisoning effects go far beyond hemoglobin poisoning. • Carbon monoxide creates reactive oxygen species and promotes nitric oxide release. • Carbon monoxide acts directly on neurologic and cardiac ion channels. • Certain oxygen therapies may not be the best therapy for carbon monoxide poisoning.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2015.05.004