In vitro human skin permeation and decontamination of 2-chloroethyl ethyl sulfide (CEES) using Dermal Decontamination Gel (DDGel) and Reactive Skin Decontamination Lotion (RSDL)

•Both DDGel and RSDL significantly removed CEES from skin.•DDGel showed higher decontamination efficiency than RSDL.•DDGel back-extracted chemicals from SC and reduced penetrating deeper skin layers. This study compared the efficiency for in vitro human skin decontamination using DDGel and RSDL. Exp...

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Bibliographic Details
Published in:Toxicology letters 2018-07, Vol.291, p.86-91
Main Authors: Cao, Yachao, Hui, Xiaoying, Zhu, Hanjiang, Elmahdy, Akram, Maibach, Howard
Format: Article
Language:English
Subjects:
CWA simulants
Dermal Decontamination Gel (DDGel)
Human skin decontamination
Reactive Skin Decontamination Lotion (RSDL)
Skin permeation
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Summary:•Both DDGel and RSDL significantly removed CEES from skin.•DDGel showed higher decontamination efficiency than RSDL.•DDGel back-extracted chemicals from SC and reduced penetrating deeper skin layers. This study compared the efficiency for in vitro human skin decontamination using DDGel and RSDL. Experiments were performed using in vitro human skin models, in which skin was mounted onto Flow-Through diffusion cells. The mass of 14-C CEES removed from skin surface after decontamination was quantitated by measuring radioactivity with a liquid scintillation spectrometer. Both decontaminants removed more than 82% of CEES from skin. DDGel skin decontamination significantly reduced toxicant amount when compared to RSDL. Mean CEES remaining in stratum corneum (SC), viable epidermis, dermis, and systemic absorption of DDGel and RSDL were, 0.12 and 0.55% (P 
ISSN:0378-4274
1879-3169
DOI:10.1016/j.toxlet.2018.04.015