Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice

• Published in: Toxicology reports 2025-06, Vol.14, p.101896, Article 101896
• Main Authors: Álvarez-Barrera, Lucila, Mateos-Nava, Rodrigo Aníbal, Hernández-Córdova, Keyla Nahomi, Lezama-Sánchez, Eduardo, Alcántara-Mejía, Víctor Alan, Rodríguez-Mercado, Juan José
• Format: Article
• Language: English
• Subjects: Abnormalities in offspring; Chromosomal aberrations; Delayed ossification; Maternal toxicity; Micronucleus; Thallium(I) acetate
• ISSN: 2214-7500; 2214-7500
• DOI: 10.1016/j.toxrep.2025.101896

The increased concentration of thallium (Tl) in the environment is a cause for concern because the entire population, including pregnant women, is exposed, and this metal crosses the placenta and reaches the conceptus during development. In biological models such as mice, some abnormalities and delays in ossification occur in the fetuses of mice administered Tl on day 7 of gestation, but exposure to environmental Tl is constant during fetal development; therefore, in this study, the effects of several administrations of TI during organogenesis on the external morphology, skeletal development and genotoxicity of fetuses were evaluated. Four groups of 10 pregnant mice were administered 5.28, 6.16, 7.4 or 9.25mg/kg body weight Tl(I) acetate intraperitoneally during fetal organogenesis. Additionally, samples were taken from fetuses from pregnant mice treated with 5.28 and 6.16mg/kg body weight to evaluate the transplacental genotoxicity. The results revealed that the 9.25mg/kg body weight dose produced maternal and fetal toxicity, and all of the treatment groups presented relatively high percentages of fetuses with external abnormalities, reduced bone ossification, and an increased percentage of liver cells with structural chromosomal aberrations (SCAs) and micronuclei (MNs) in blood cells. These results show that Tl(I) acetate administered during organogenesis produces abnormalities, including a delay in ossification and transplacental genotoxicity, in mouse fetuses. These findings are important because Tl has negative effects on development and may affect the health of offspring in the future because it can damage genetic material. [Display omitted] •The administration of the 9.25mg/kg body weight dose of Tl(I) acetate during organogenesis produced maternal and fetal toxicity.•The administrations of 5.28, 6.16, 7.4 or 9.25mg/kg body weight doses of Tl(I) acetate administered ip during fetal organogenesis, produced an increase in the percentage of fetuses with external abnormalities and reduced bone ossification.•Doses of 5.28 and 6.16mg/kg body weight of Tl(I) acetate administered ip during fetal organogenesis, produced an increase in the percentage of liver cells with SCAs and an increase in the percentage of blood cells with MNs.