Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo

Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly(o-phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This review highlights PEC sensitivity an...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2008, Vol.27 (1), p.78-88
Main Authors: O’Neill, Robert D., Rocchitta, Gaia, McMahon, Colm P., Serra, Pier A., Lowry, John P.
Format: Article
Language:English
Subjects:
Analytical chemistry
Ascorbic acid interference
Biological and medical sciences
Biosensors
Biotechnology
Brain monitoring
Chemistry
Electrochemical methods
Electropolymerization
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General, instrumentation
Glucose
Glutamate
H 2O 2 permeability
Methods. Procedures. Technologies
Polymer-modified electrode
Various methods and equipments
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Summary:Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly(o-phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This review highlights PEC sensitivity and selectivity parameters, which allow development of the basic design in a systematic way in order to improve their performance and to diversify the analyte range of these novel probes of brain function.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2007.11.008