Assessment of the chemical and enantiomeric purity of organic reference materials

This review evaluates commonly used methodologies for assessing the chemical purity of organic reference materials. Direct assay of the principal component can be established by methodologies such as gas chromatography, liquid chromatography (LC), quantitative nuclear magnetic resonance (NMR), eleme...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2011-04, Vol.30 (4), p.628-640
Main Authors: Yip, Yiu-chung, Wong, Siu-kay, Choi, Sik-man
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemical purity
Chemistry
Chromatographic methods and physical methods associated with chromatography
Differential scanning calorimetry
Enantiomeric purity
Exact sciences and technology
Gas chromatographic methods
Gas chromatography
Inductively coupled plasma mass spectrometry
Ion chromatography
Karl Fischer titration
Liquid chromatography
Organic reference material
Other chromatographic methods
Quantitative nuclear magnetic resonance
Spectrometric and optical methods
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Summary:This review evaluates commonly used methodologies for assessing the chemical purity of organic reference materials. Direct assay of the principal component can be established by methodologies such as gas chromatography, liquid chromatography (LC), quantitative nuclear magnetic resonance (NMR), elemental analysis and titrimetry. Measurements of detectable impurity components mainly include determination of water or moisture content, and analysis of residual solvents, and organic and inorganic impurities. To complete assessment of chemical purity, it is necessary to determine the enantiomeric purity of chiral organic reference materials. Promising methodologies for analysis include LC with chiral stationary phases, capillary electrophoresis using chiral selectors, and NMR with chemical-shift reagents.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2010.12.003