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Applications of particle-tracking analysis to the determination of size distributions and concentrations of nanoparticles in environmental, biological and food samples
The manufacture of nanoparticles (NPs) and nanomaterial-based products is rapidly increasing and their possible occurrence in environment, food or biological tissue is becoming of concern for ecological and human health. However, there is a lack of suitable methods to analyze and to characterize NPs...
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Published in: | TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2011-03, Vol.30 (3), p.473-483 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The manufacture of nanoparticles (NPs) and nanomaterial-based products is rapidly increasing and their possible occurrence in environment, food or biological tissue is becoming of concern for ecological and human health. However, there is a lack of suitable methods to analyze and to characterize NPs in low concentrations in complex matrixes. We compare several particle-tracking methods using video microscopy and a new technique called nanoparticle-tracking analysis (NTA). Video microscopy has been widely applied to investigate particle movement in biological samples, micro-rheology, and velocity profiles in fluids, whilst NTA was devised for determination of size distributions and concentrations in liquid samples. We critically discuss the advantages and the limitations of NTA for such applications. |
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ISSN: | 0165-9936 1879-3142 |
DOI: | 10.1016/j.trac.2011.01.005 |