Hydrophilic interaction chromatography

► Hydrophilic interaction (liquid) chromatography (HILIC) separation systems. ► HILIC has great potential applications for separations of polar compounds. ► HILIC is an interesting alternative for separations that are problematic. In the early 1990s, hydrophilic interaction (liquid) chromatography (...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2012-07, Vol.37, p.48-60
Main Authors: Gama, Mariana Roberto, da Costa Silva, Raquel Gomes, Collins, Carol H., Bottoli, Carla B.G.
Format: Article
Language:English
Subjects:
Acetonitrile
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Hydrophilic interaction chromatography
Liquid chromatography
Neurotransmitter
Nucleoside
Nucleotide
Organic solvent
Other chromatographic methods
Pharmaceutical
Polar compound
Separation
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Summary:► Hydrophilic interaction (liquid) chromatography (HILIC) separation systems. ► HILIC has great potential applications for separations of polar compounds. ► HILIC is an interesting alternative for separations that are problematic. In the early 1990s, hydrophilic interaction (liquid) chromatography (HILIC) emerged as a new separation method. HILIC is becoming increasingly popular for the separation of polar compounds in aqueous-organic mobile phases rich in organic solvents (usually acetonitrile). It has become important for the separation of pharmaceuticals, neurotransmitters, nucleosides, nucleotides and other compounds. This review presents an overview of HILIC separation systems, comparing it to several other recently described modes.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2012.03.009