Electrochemical biosensors based on nanomodified screen-printed electrodes: Recent applications in clinical analysis

•Screen-printed electrodes modified with nanomaterials provide better analytical features.•Paper based electrochemical devices provide easy and cost effective analyses.•Label-free innovative electrochemical immunosensors as screening methods to detect important metabolites.•Novel DNA-based electroch...

Full description

Saved in:
Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2016-05, Vol.79, p.114-126
Main Authors: Arduini, Fabiana, Micheli, Laura, Moscone, Danila, Palleschi, Giuseppe, Piermarini, Silvia, Ricci, Francesco, Volpe, Giulia
Format: Article
Language:English
Subjects:
Clinical analysis
DNA-based sensors
Enzymatic biosensors
Immunosensors
Nanomaterials
Paper-based electrochemical sensors
Screen-printed electrodes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Screen-printed electrodes modified with nanomaterials provide better analytical features.•Paper based electrochemical devices provide easy and cost effective analyses.•Label-free innovative electrochemical immunosensors as screening methods to detect important metabolites.•Novel DNA-based electrochemical disposable sensors: new devices to measure low concentrations of clinical markers. This review addresses recent advances in the development of screen-printed electrode based biosensors modified with different nanomaterials such as carbon nanotubes, graphene, metallic nanoparticles as gold, silver and magnetic nanoparticles, and mediator nanoparticles (Prussian Blue, Cobalt Phthalocyanine, etc.), coupled with biological recognition elements such as enzymes, antibodies, DNA and aptamers to obtain probes with improved analytical features. Examples of clinical applications are illustrated, together with examples of paper-based electrochemical devices, of multiple detections using arrays of screen printed electrodes, and of the most recent developments in the field of wearable biosensors. Also the use of smartphones as final detectors is briefly depicted.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2016.01.032