Determination of nucleosides and nucleotides in food samples by using liquid chromatography and capillary electrophoresis

Nucleosides and nucleotides are intracellular compounds that are precursors of nucleic acids and which take part in various regulatory and metabolic functions. Although they can be synthesized endogenously, a dietary supplement is beneficial to the organism under certain conditions when the demand f...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2017-07, Vol.92, p.12-31
Main Authors: Domínguez-Álvarez, Javier, Mateos-Vivas, María, Rodríguez-Gonzalo, Encarnación, García-Gómez, Diego, Bustamante-Rangel, Myriam, Delgado Zamarreño, María-Milagros, Carabias-Martínez, Rita
Format: Article
Language:English
Subjects:
Capillary electrophoresis
Food analysis
Infant foods
Liquid chromatography
Nucleosides
Nucleotides
Sample treatment
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Summary:Nucleosides and nucleotides are intracellular compounds that are precursors of nucleic acids and which take part in various regulatory and metabolic functions. Although they can be synthesized endogenously, a dietary supplement is beneficial to the organism under certain conditions when the demand for these semi-essential nutrients is high. The analysis of these compounds in food is, therefore, of great importance if we are to improve and ensure food quality. This review summarizes the chromatographic and capillary electrophoresis analytical methods described for the analysis of nucleosides and nucleotides in foodstuffs, including sample treatment steps used for isolation and cleanup. In addition, the future prospects in the analysis of these compounds in food matrices have also been included. •The determination of nucleosides and nucleotides in food samples is reviewed.•The issue of the separation & detection of nucleosides and nucleotides is discussed.•Relevant applications in LC and CE are presented.•The importance of the analysis of infant and non-infant food samples is emphasised.•Future trends are identified.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2017.04.005