Current challenges and future prospects in chromatographic method development for pharmaceutical research

A survey of different strategies for chromatographic method development in pharmaceutical research and development is presented. Owing to the widespread utilization of chromatography within diverse areas of pharmaceutical research, a variety of strategies for method development have arisen. We surve...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 2017-10, Vol.95, p.36-46
Main Authors: Mattrey, Frederick T., Makarov, Alexey A., Regalado, Erik L., Bernardoni, Frank, Figus, Margaret, Hicks, Michael B., Zheng, Jinjian, Wang, Lin, Schafer, Wes, Antonucci, Vincent, Hamilton, Simon E., Zawatzky, Kerstin, Welch, Christopher J.
Format: Article
Language:English
Subjects:
Allotrope Foundation
Analytical method modeling
Liquid chromatography
Method development workflow
Method screening
Pharmaceutical analysis
Quality-by-design
Supercritical fluid chromatography
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Summary:A survey of different strategies for chromatographic method development in pharmaceutical research and development is presented. Owing to the widespread utilization of chromatography within diverse areas of pharmaceutical research, a variety of strategies for method development have arisen. We survey the current state of the art, discuss recent trends and approaches and highlight future prospects and capability gaps. •New trends in chromatographic method development.•Recent developments in chromatographic screening, modeling and knowledge management.•Evolution of strategies for pharmaceutical method development in SFC and HPLC.•The future outlook for improved method development algorithms and intelligent systems.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2017.07.021